p18
cell-loc
synapses
minor
params
smalldt
onsurface
migliore-1a
rallpack3
cwvclamp
vcsteps
rallpack1
smartrec
ivconv
ivconvm
mean-variance-iv-stoch
stochdet
channel-functions
stimtest
functest
migliore-pass
psd
cianmar30
mean-variance
rallpack2
rallpack3-stoch
rallpack3-stoch2
chowwhite
multirec
mainen
soma-spikes-stochastic
soma-spikes-continuous
p1-f1-mean-variance
rallpack1-IE
rallpack2-IE
singlecpt
synstim
resonance
manychannels

migliore-pass (runpass.xml)

Migliore et al CA1 pyramidal cell

Total CPU time 0.4900 seconds; at 11:55:10 Thu 24 Sep 2009

CompartmentsStochastic
channels / cpmts
Continuous
channels / cpmts
Non Gated
channels / cpmts
CPU Time / s
11050 / 01748 / 6640 / 0 0.490

Morphology: morph59

 

Predefined views

whole

first

decay

All files

ModelPreprocessedOutupt dataReference data etc
runpass.xml
morph59.xml
membrane-pass.xml
environment.xml
recording-pass.xml
leak-Na.xml
leak-K.xml
psics-out.ppp
log.txt
psics-out.sum
psics-out.dat
psics-out.txt

Model

Archive file of the complete model: migliore-pass.jar

runpass.xml

<PSICSRun timeStep="0.05ms" runTime="120ms" startPotential="-65mV"
	morphology="morph59"
	environment="environment"
	properties="membrane-pass"
	access="recording-pass"
	stochThreshold="0">
	<StructureDiscretization baseElementSize="15.um"/>
	<ChannelDiscretization vMin="-100mV" vMax="60mV" deltaV="2mV"/>

	<info>Migliore et al CA1 pyramidal cell</info>


	<ViewConfig>
		<LineGraph width="500" height="400">
		<XAxis min="0" max="250" label="time / ms"/>
		<YAxis min="-80" max="60" label="potential / mV"/>

	    <LineSet file="psics-out.txt" color="red" show="1"/>
 		<LineSet file="psics-out.txt" color="blue" show="2"/>
       <!--
        <LineSet file="psics-out.txt" color="green" show="3"/>
        -->

		<View id="whole" xmin="-10." xmax="120." ymin="-80." ymax="20."/>

		<View id="first" xmin="-2" xmax="20" ymin="-80." ymax="20."/>
	    <View id="decay" xmin="4" xmax="40" ymin="-65." ymax="-55."/>


		</LineGraph>
	</ViewConfig>
</PSICSRun>

morph59.xml (truncated)

<morphml id="morph59">
<!-- XML file generated by NEURON 5.9 ModelViewer -->
<!-- Authors: Michael Hines and Sushil Kambampati -->
<!-- Yale University -->
<!-- Date: Fri Sep  7 12:52:05 BST 2007 -->
<cells>
<cell name="soma[0]">
  <segments>
    <segment id="1" name = "Seg0_soma[0]" cable = "0">
      <proximal x="0" y="0" z="0" diameter="3.4"/>
      <distal x="0.25" y="0" z="0" diameter="3.4"/>
    </segment>
    <segment id="2" name = "Seg1_soma[0]" parent="1" cable = "0">
      <distal x="0.5" y="0" z="0" diameter="3.4"/>
    </segment>
    <segment id="671" name = "Seg0_basal[41]" parent="1" cable = "181">
      <proximal x="0" y="0" z="0" diameter="1"/>
      <distal x="-4.38737" y="1.85495" z="0" diameter="1"/>
    </segment>
    <segment id="672" name = "Seg1_basal[41]" parent="671" cable = "181">
      <distal x="-8.77474" y="3.7099" z="0" diameter="1"/>
    </segment>
    <segment id="606" name = "Seg0_basal[23]" parent="1" cable = "163">
      <proximal x="0" y="0" z="0" diameter="1"/>
      <distal x="-5.95875" y="0.799243" z="0" diameter="1"/>
    </segment>
    <segment id="607" name = "Seg1_basal[23]" parent="606" cable = "163">
      <distal x="-11.9175" y="1.59849" z="0" diameter="1"/>
    </segment>
    <segment id="593" name = "Seg0_basal[20]" parent="1" cable = "160">
      <proximal x="0" y="0" z="0" diameter="0.4"/>
      <distal x="-8.98517" y="-1.20517" z="0" diameter="0.4"/>
    </segment>
    <segment id="594" name = "Seg1_basal[20]" parent="593" cable = "160">
      <distal x="-26.9555" y="-3.61552" z="0" diameter="0.4"/>
    </segment>
    <segment id="595" name = "Seg2_basal[20]" parent="594" cable = "160">
      <distal x="-35.9407" y="-4.82069" z="0" diameter="0.4"/>
    </segment>
    <segment id="517" name = "Seg0_basal[0]" parent="1" cable = "140">
      <proximal x="0" y="0" z="0" diameter="0.8"/>
      <distal x="-1.33023" y="-0.562414" z="0" diameter="0.8"/>
    </segment>
    <segment id="518" name = "Seg1_basal[0]" parent="517" cable = "140">
      <distal x="-2.66047" y="-1.12483" z="0" diameter="0.8"/>
    </segment>
    <segment id="3" name = "Seg0_soma[1]" parent="2" cable = "1">
      <proximal x="0.5" y="0" z="0" diameter="3.4"/>
      <distal x="0.55" y="0" z="0" diameter="3.4"/>
    </segment>
    <segment id="4" name = "Seg1_soma[1]" parent="3" cable = "1">
      <distal x="0.6" y="0" z="0" diameter="3.4"/>
    </segment>
    <segment id="736" name = "Seg0_basal[59]" parent="672" cable = "199">
      <proximal x="-8.77474" y="3.7099" z="0" diameter="0.4"/>
      <distal x="-15.8252" y="10.9693" z="0" diameter="0.4"/>
    </segment>
    <segment id="737" name = "Seg1_basal[59]" parent="736" cable = "199">
      <distal x="-29.9261" y="25.4881" z="0" diameter="0.4"/>
    </segment>

 - and 2829 more lines -

membrane-pass.xml

<CellProperties id="membrane-pass"
      cytoplasmResistivity="150ohm_cm"
      membraneCapacitance="1.0uF_per_cm2">

	<!--   <Exclusion either="*apical*" or="*soma*"/> -->

  	<PassiveProperties region="*apical*" membraneCapacitance="2uF_per_cm2"/>
  	<PassiveProperties region="*basal*" membraneCapacitance="2uF_per_cm2"/>
	<PassiveProperties region="*axon*" cytoplasmResistivity="150ohm_cm"/>
	<PassiveProperties region="*soma*" membraneCapacitance="1uF_per_cm2"/>


	<ChannelPopulation channel="leak-Na" density="0.0512per_um2"/>
	<ChannelPopulation channel="leak-K" density="0.0512per_um2"/>


<!--

   <CellRegion match="*basal*">
   <ChannelPopulation channel="leak-Na" density="0.0512per_um2"/>
	<ChannelPopulation channel="leak-K" density="0.0512per_um2"/>
	</CellRegion>


	<CellRegion match="*apical*">
   	    <ChannelPopulation channel="leak-Na" density="0.0512per_um2"/>
	    <ChannelPopulation channel="leak-K" density="0.0512per_um2"/>
    </CellRegion>

 -->



    <DensityAdjustment maintain="-65mV" vary="leak-Na, leak-K"/>

</CellProperties>

environment.xml

<CellEnvironment id="environment" temperature="34Celsius">
	<Ion id="K" name="Potassium" reversalPotential="-90mV"/>
	<Ion id="Na" name="Sodium" reversalPotential="55mV"/>
</CellEnvironment>

recording-pass.xml

<Access id="recording-pass">

	<CurrentClamp at="4" hold="0nA">
		<CurrentPulse start="4ms" duration="1.2ms" to="2nA"/>
		<CurrentPulse start="44ms" duration="1.2ms" to="2nA"/>
		<CurrentPulse start="84ms" duration="1.2ms" to="2nA"/>
	</CurrentClamp>

	<VoltageRecorder at="Seg0_apical[12]"/>

</Access>

leak-Na.xml

<KSChannel id="leak-Na" gSingle="5pS" permeantIon="Na">
	<OpenState id="o1"/>
	<ClosedState id="c1"/>
	<FixedRateTransition from="o1" to="c1" forward="3.per_ms" reverse="7.per_ms"/>
</KSChannel>

leak-K.xml

<KSChannel id="leak-K" gSingle="5pS" permeantIon="K">
	<OpenState id="o1"/>
	<ClosedState id="c1"/>
	<FixedRateTransition from="o1" to="c1" forward="3.per_ms" reverse="7.per_ms"/>
</KSChannel>